PUBLICATIONS
1.
Natarajan, D. and S.T. Santhiya (1990). Cytogenetic Damage in
Operation Theatre Personnel. Anaesthesia, 45, 574-577.
2. Natarajan D, Boulter CA (1995).
Isolation of genomic sequences flanking a retroviral insertion
site using a novel PCR-based method. Gene 161, 195-198.
3. Natarajan D, Boulter CA (1995)
A lacZ-hygromycin fusion gene and its use in a gene trap vector
for marking embryonic stem cells. Nucleic Acids Res 23, 4003-4004
4. Snaith MR, Natarajan D, Taylor
LB, Choi CP, Martinerie C, Perbal B, Schofield PN, Boulter CA
(1996). Genomic structure and chromosomal mapping of the mouse
nov gene. Genomics 38, 425-428
5. Pachnis V, Durbec P, Taraviras
S, Grigoriou M, Natarajan D (1998) III. Role Of the RET signal
transduction pathway in development of the mammalian enteric nervous
system.Am J Physiol 1275(2 Pt 2),G183-G186
6. Boulter CA, Natarajan D. (1999).
A PCR-based method for isolation of genomic DNA flanking a known
DNA sequence. Curr Issues Mol Biol. 1 (1-2): 47-52.
7. Dipa Natarajan, Maria Grigoriou,
Camelia V. Marcos-Gutierrez, Chris Aitkins and Vassilis Pachnis
(1999). Multipotential progenitors of the mammalian enteric nervous
system capable of colonising aganglionic bowel in organ culture.
Development 126, 157-168.
8. Dipa Natarajan, Vassilis Pachnis
(2000). Development of the Enteric Nervous System. Chapter in
“Development of the Gastrointestinal tract”, Ian Sanderson
and W. Allan Walker: 197-210.
9. Natarajan D, Andermarcher E, Schofield
PN, Boulter CA. (2000). Mouse Nov gene is expressed in hypaxial
musculature and cranial structures derived from neural crest cells
and placodes. Dev.Dyn 219 (3): 417-425.
10. Dipa Natarajan, Camelia Marcos-Gutierrez,
Vassilis Pachnis and Esther de Graaff (2002). Requirement of signalling
by receptor tyrosine kinase RET for the directed migration of
enteric nervous system progenitor cells during mammalian embryogenesis.
Development 129(22):5151-60.
11. Bondurand N*, Natarajan D*, Thapar
N*, Atkins C, Pachnis V. (2003). Neuron and glia generating progenitors
of the mammalian enteric nervous system isolated from foetal and
postnatal gut cultures. Development. 130(25):6387-400. (* joint
first authors).
12. Bondurand N*, Natarajan D*, Barlow
A*, Thapar N, Pachnis V. (2006). Maintenance of mammalian enteric
nervous system progenitors by SOX10 and endothelin 3 signalling.
Development. 133(10):2075-86. (* joint first authors).
13. Jongen JL, Jaarsma D, Hossaini
M, Natarajan D, Haasdijk ED, Holstege JC. (2007). Distribution
of RET immunoreactivity in the rodent spinal cord and changes
after nerve injury. J Comp Neurol. Feb 20;500(6):1136-53.
14. Veiga-Fernandes H, Coles MC,
Foster KE, Patel A, Williams A, Natarajan D, Barlow A, Pachnis
V, Kioussis, D. Tyrosine kinase receptor RET is a key regulator
of Peyer's Patch organogenesis. Nature 2007, Mar 29;446(7135):547-51.
15. Silvia Bogni, Paul Trainor, Dipa
Natarajan, Robb Krumlauf and Vassilis Pachnis. (2008). Non cell-autonomous
effects of Ret deletion in early enteric neurogenesis. Development
135, 3007-3011.
16. Ryo Hotta, Dipa Natarajan and
Nikhil Thapar. (2009). Potential of cell therapy to treat pediatric
motility disorders. Seminars in Pedriatic Surgery,18, 263-273.
17. Hotta R, Natarajan D, Burns AJ,
Thapar N. (2011). Stem
cells for GI motility disorders. Curr Opin Pharmacol. Dec;11(6):617-23.
18. Kinsler VA, Anderson G, Latimer
B, Natarajan D, Healy E, Moore GE, Sebire, NJ. (2013) Immunohistochemical
and ultrastructural features of congenital melanocytic naevus
cells support a stem-cell phenotype. Br.
J. Dermatol. Aug;169(2):374-83.
19. Delalande JM*, Natarajan D*,
Vernay B, Finlay M, Ruhrberg C, Thapar N, Burns AJ. (2014). Vascularisation
is not necessary for gut colonisation by enteric neural crest
cells. Dev Biol. 385(2):220-9. (* joint first authors)
20. Natarajan D, Cooper J, Choudhury
S, Delalande JM, McCann C, Howe SJ, Thapar N, Burns AJ. (2014).
Lentiviral
labeling of mouse and human enteric nervous system stem cells
for regenerative medicine studies. Neurogastroenterol Motil.
(10):1513-8.
21. Binder E*, Natarajan D*, Cooper
J, Kronfli R, Cananzi M, Delalande JM, McCann C, Burns AJ, Thapar
N. (2015). Enteric neurospheres are not specific to neural crest
cultures: implications for neural stem cell therapies. PLoS
One.10(3) (* joint first authors).
22. Stathopoulou A, Natarajan D,
Nikolopoulou P, Patmanidi AL, Lygerou Z, Pachnis V, Taraviras
S. (2015). Inactivation
of Geminin in neural crest cells affects the generation and maintenance
of enteric progenitor cells, leading to enteric aganglionosis.
Dev Biol. 2015 Dec 3. pii: S0012-1606(15)30165-2.
23. Chapter 46: Cellular Based Therapies
for Pediatric GI Motility Disorders.
Ryo Hotta, Dipa Natarajan, Alan J. Burns and Nikhil Thapar.
2nd edition of the textbook of Pediatric neurogastroenterology
24. Julie E. Cooper, Conor J. McCann,
Dipa Natarajan, Shanas Choudhury, Alan J. Burns and Nikhil Thapar
(2016). In Vivo Transplantation of Enteric Neural Crest Cells
into Mouse Gut; Engraftment, Functional integration and Long-Term
Safety. PLOS One. Jan 29;11(1):e0147989. doi: 10.1371/journal.pone.0147989.
eCollection 2016.
25. Francesca Bianco, Elena Bonora,
Dipa Natarajan, Manuela Vargiolu, Nikhil Thapar, Francesco Torresan,
Fiorella Giancola, Elisa Boschetti, Umberto Volta, Franco Bazzoli,
Maurizio Mazzoni, Marco Seri, Paolo Clavenzani, Vincenzo Stanghellini,
Catia Sternini, and Roberto De Giorgio. (2016). Prucalopride exerts
neuroprotection in human enteric neurons. Am J Physiol Gastrointest
Liver Physiol 310: G768 –G775, 2016. Rapid Report. doi:10.1152/ajpgi.00036.2016
26. Conor J. McCann, Julie E. Cooper,
Dipa Natarajan, Benjamin Jevans, Laura E. Burnett, Alan J. Burns
& Nikhil Thapar (2017). Transplantation of enteric nervous
system stem cells rescues nitric oxide synthase deficient mouse
colon. Nature Communications 8, 15937
27. Daniel Perea, Jordi Guiu, Bruno
Hudry, Chrysoula Konstantinidou, Alexandra Milona, Dafni Hadjieconomou,
Thomas Carroll, Nina Hoyer, Dipa Natarajan, Jukka Kallijärvi,James
A Walker, Peter Soba, Nikhil Thapar, Alan J Burns, Kim B Jensen
and Irene Miguel-Aliaga. 2017. Ret receptor tyrosine kinase sustains
proliferation and tissue maturation in intestinal epithelia.
EMBO J. 2017 Oct 16; 36(20): 3029–3045.
28. Urbani L, Camilli C, Phylactopoulos
DE, Crowley C, Natarajan D, Scottoni F, Maghsoudlou P, McCann
CJ, Pellegata AF, Urciuolo A, Deguchi K, Khalaf S, Aruta SF, Signorelli
MC, Kiely D, Hannon E, Trevisan M, Wong RR, Baradez MO, Moulding
D, Virasami A, Gjinovci A, Loukogeorgakis S, Mantero S, Thapar
N, Sebire N, Eaton S, Lowdell M, Cossu G, Bonfanti P, De Coppi
P. 2018. Multi-stage bioengineering of a layered oesophagus with
in vitro expanded muscle and epithelial adult progenitors. Nat
Commun. 2018 Oct 16;9(1):4286
29. McCann CJ, Alves MM, Brosens
E, Natarajan D, Perin S, Chapman C, Hofstra RM, Burns AJ, Thapar
N. 2019. Neuronal Development and Onset of Electrical Activity
in the Human Enteric Nervous System. Gastroenterology.
2019 Apr;156(5):1483-1495.
30. Edoardo D’Angelo, Dipa
Natarajan, Francesca Sensi, Omolola Ajayi, Matteo Fassan, Enzo
Mammano, Pierluigi Pilati, Piero Pavan, Silvia Bresolin, Melissa
Preziosi, Rosa Miquel, Yoh Zen, Shilpa Chokshi, Krishna Menon,
Nigel Heaton, Gaya Spolverato, Martina Piccoli, Roger Williams,
Luca Urbani and Marco Agostini. 2020. Patient-Derived Scaffolds
of Colorectal Cancer Metastases as an Organotypic 3D Model of
the Liver Metastatic Microenvironment. Cancers 2020, 12, 364;
doi:10.3390/cancers12020364
31. Lisa Sassi, Omolola Ajayi, Sara
Campinoti, Dipa Natarajan, Claire McQuitty,
Riccardo Rayan Siena, Sara Mantero, Paolo De Coppi, Alessandro
F. Pellegata, Shilpa Chokshi and Luca Urbani (2021). A Perfusion
Bioreactor for Longitudinal Monitoring of Bioengineered Liver
Constructs. Nanomaterials 2021, 11, 275. https://doi.org/10.3390/nano11020275
32.
Jean Marie Delalande, Nandor Nagy, Conor J. McCann, Dipa Natarajan,
Julie E. Cooper, Gabriela Carreno, David Dora, Alison Campbell,
Nicole Laurent,
Polychronis Kemos, Sophie Thomas, Caroline Alby, Tania Attie-Bitach,
Stanislas Lyonnet, Malcolm P. Logan, Allan M. Goldstein, Megan
G. Davey,
Robert M.W. Hofstra, Nikhil Thapar & Alan J. Burns. (2021).
TALPID3/KIAA0586 regulates multiple aspects of neuromuscular patterning
during gastrointestinal development in animal models and human.
bioRxiv preprint doi: https://doi.org/10.1101/2021.05.28.446103
33.
Natarajan D, McCann C, Dattani J, Pachnis V and Thapar N (2022) Multiple Roles of Ret Signalling During Enteric Neurogenesis. Front. Mol. Neurosci. 15:832317. doi: 10.3389/fnmol.2022.832317
